alternative treatment for scleroderma

the .gov means it’s official. federal government websites often end in .gov or .mil. before sharing sensitive information, make sure you’re on a federal government site. the site is secure. the https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. scleroderma is an autoimmune disease of the connective tissue characterized by fibrosis and thickening of various tissues. it can be limited to the skin or affect multiple organs, and its course ranges from slowly to rapidly progressive. penicillamine, glucocorticoids, and other drugs are used to treat scleroderma, but none of these treatments has a high degree of efficacy. this article reviews several promising natural treatments for scleroderma, including para-aminobenzoic acid, vitamin e, vitamin d, evening primrose oil, estriol, n-acetylcysteine, bromelain, and an avocado/soybean extract.

this study is the result of a search in pubmed, scopus, and cochrane library with “scleroderma”, “systemic sclerosis”, “plant”, “herb”, and “phytochemical” keywords. however, the incidence and prevalence of various autoimmune diseases are rising in women [6]. thus, usage of plant origin active substances in human diet might be an effective approach to regulate immune diseases and to maintain the body health [4]. the prevalence, incidence, and clinical features of the disease change per the geographic place, where the severity and complication of scleroderma were higher in african-americans in comparison with caucasians due to the difference in the autoantibodies that were detected [34–39]. an early pathological alteration in the scleroderma is vascular damage, where the function of endothelial cells and the ultrastructure of microvessels are altered [48, 63]. the correlation between the severity of the scleroderma and the level of tgf-β is controversial. it is activated by insulin and growth factors via the activation of phosphoinositide-3-kinase (pi3k). the trafficking of lymphocytes and immune cells in general is regulated by the extracellular matrix components [91]. when the level of ros, rnos, and hocl is higher than the capacity of the antioxidant system in the cells, oxidative stress happens.

high percentages of apoptotic endothelial cells were found in the dermis of systemic sclerosis patients and local cutaneous sclerosis biopsies. the serum level and dermal fibroblast level of mir-92a were found to be high in systemic sclerosis patients, leading to downregulation of metalloprotease-1 and collagen accumulation [128]. a high percentage of flavonoids and terpenoids is implicated in the pharmacological activities of g. biloba [135]. xuefu zhuyu decoction is a herbal decoction used in traditional chinese medicine for enhancing blood circulation and treatment of atherosclerosis and neurodegenerative disease. e-selectin is a type of selectin molecule that plays an important role in the inflammation process and is activated by cytokines. administration of dipropyltetrasulfide in hocl-induced systemic sclerosis mice reduced the expressions of α-sma and psmad2/3 in the skin tissue. (meliaceae) and is used in indian traditional medicine for the treatment of many diseases. withaferin a is one of the active compounds derived from withania somnifera (l.) dunal (solanaceae) and used in indian traditional medicine with known applications for the treatment of immunological and inflammatory diseases [176]. article of the year award: outstanding research contributions of 2021, as selected by our chief editors.

biofeedback may help some people with scleroderma better control the temperature in their hands and feet, although studies are mixed. other mind this article reviews several promising natural treatments for scleroderma, including para-aminobenzoic acid, vitamin e, vitamin d, evening primrose oil, past research suggests that vitamin e may have antifibrotic action and help to curb the buildup of excess tissue. symptoms of scleroderma., related health topics, related health topics.

this chapter will review some of the more common alternative therapies for scleroderma. this review is not an approval of any alternative therapy. information herbs turmeric (curcuma longa). lab studies show that turmeric reduces inflammation. gotu kola (centella asiatica), for blood vessel health natural treatment of scleroderma take omega-3 fatty acids, such as fish oil, daily. massage and physical therapy can improve circulation., .

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