aim: the aim of our study was to find the antifungal activities at mic of selected fifteen plant leaves extracts prepared in three different solutions (methanol and ethanol) against the opportunistic pathogen candida albicans isolated from oral cavity infections. candida albicans is the most prevalent fungal species associated with oral leukoplakia and may contribute to malignant transformation of candida leukoplakia. the prospective study was done to explore the plants having antifungal activity towards candida albicans which can further be used in treatment of oral candidal infection and in oral mucosal lesions. all of the fractions were prepared in two to three fold dilutions.
the minimum inhibitory concentration (mic) of the extracts was determined for the test organisms in triplicates. to a 0.5 ml of varying concentrations of the extracts (20.0, 15.0, 10.0, 5.0 and 1.0 mg/ml), 2 ml of nutrient broth was added (so the extracts were dilute by a factor of 5). the mean and the s.d of each herbal extracts were used to compute the calculated t-value. in fact, natural products play a major role in controlling infections and treatment by inhibiting the growth of responsible pathogen. as by use of these products will totally vanishes the fungal colony from oral cavity without resulting in any side effects or toxicity like drugs.
the majority of used antifungal treatments have various drawbacks in terms of toxicity, efficacy as well as cost and their frequent use has also led to the emergence of resistant strains. present chapter focused on the work done in the field of antifungal activities of various plant components and novel approaches which will be the future prospective for the new drug discoveries and providing better antifungal therapy. medicinal plants have also been reported in traditional systems of medicine for the treatment of both human and animal mycoses, and are considered to be a valuable source for the discovery of new antifungal drugs. many herbal drugs using novel drug delivery system has made a mark in the market and few of them are in the developmental stage in the laboratory .
there are various herbal and synthetic liposomes are prepared for the effective treatment of different skin diseases. in this drug delivery system inner phase stores the drugs and because of its contact with tissue directly drug release is slow. ethosomes are composed of phospholipids and ethanol and are in the form of sac. ethosomes are found in the form of cream and gel for better patient compliance . the form can be of slabs, films and nanoparticle coating .
in ethanolic extract the best antifungal activity was given by withania somnifera, zingiber officinale, curcuma longa, swertia chirata, euphorbia hirta, there are few controlled clinical trials of herbal antifungal medicines. the most thoroughly clinically tested is tea tree oil, which holds some promise. all 2. plants having antifungal activity ; 3. curcuma longa, zingiberaceae ; 4. piptadenia colubrina, mimosaceae ; 5. schinus terebinthifolius, anacardiaceae ; 6., antifungal herbs for skin, antifungal herbs for skin, antifungal herbs and spices, antifungal herbal extracts, chinese herbs for fungal infections.
in the discovery of fungal overgrowths, whether yeast or mold, treatment options are vast. these 5 herbs discussed: goldenseal, echinacea, grapefruit seed extract, garlic, and black walnut are options that should be considered. cao huang gui xiang (chgx) formula, a chinese herbal medicine, has been empirically used for the treatment of candida infections. in the present antifungal herbs: healing allies california bay (umbellularia californica) = this native californian tree is best used externally in tincture or strong tea popular antifungal supplements include caprylic acid, grapefruit seed extract, and, antifungal foods, antifungal herbs for lungs.
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