although ginger is generally considered to be safe (kaul and joshi 2001), the lack of a complete understanding of its mechanisms of action suggests caution in its therapeutic use (wilkinson 2000a). in the thirteenth and fourteenth centuries, the value of a pound of ginger was equivalent to the cost of a sheep. of the bioactive pungent components of jamaican ginger, including -, -, and -gingerols and -shogaol, -gingerol appears to be the most abundant pungent bioactive compound in most of the oleoresin samples studied (bailey-shaw et al. a method has been developed for the simultaneous quantification of -, -, and -gingerol and -shogaol in rat plasma in pharmacokinetic studies after oral administration of ginger oleoresin (wang et al. the presence of oxidative stress is associated with numerous diseases and a common mechanism often put forth to explain the actions and health benefits of ginger is associated with its antioxidant properties (aeschbach et al. ginger consumption has also been reported to decrease lipid peroxidation and normalize the activities of superoxide dismutase and catalase, as well as gsh and glutathione peroxidase, glutathione reductase, and glutathione-s-transferase, in rats (ahmed et al. evidence does seem to suggest that ginger and some of its components are effective antioxidants in vitro. more recently, the effectiveness of a crude ginger extract was compared with a fraction containing only gingerols and derivatives to inhibit joint swelling in the streptococcal cell wall-induced arthritis animal model of rheumatoid arthritis (funk et al. in humans, one study showed no difference between placebo and ginger in patients with osteoarthritis of the hip or knee (bliddal et al. this idea was supported by the results of a randomized, double-blind trial in which healthy volunteers reported that ginger effectively accelerated gastric emptying and stimulated antral contractions (wu et al. a follow-up study also indicated that 1 g of ginger might be effective in reducing the subjective severity of seasickness in naval cadets on the high seas (grontved et al. a systematic review of the results of other double-blind, randomized, controlled trials, uncontrolled trials, case reports, and observational studies indicated that ginger is superior to placebo and as effective as vitamin b6 in relieving the severity of nausea and vomiting, with no reported side effects or adverse effects on pregnancy (borrelli et al. however, the effectiveness of ginger in preventing postoperative nausea and vomiting has been disputed (visalyaputra et al. in contrast, at least one trial indicated that ginger was not effective in reducing the incidence of postoperative nausea and vomiting in patients undergoing gynecologic laparoscopy (eberhart et al.
because the cxcr4 mediates homing of tumor cells to specific organs that express its ligand, cxcl12, zerumbone was suggested as a potential suppressor of cancer metastasis and was effective in suppressing cxcr4 in a variety of cancers, including those of the pancreas, lung, kidney, and skin (sung et al. ginger extract and especially -gingerol were reported to effectively decrease proliferation of yyt colon cancer cells and the angiogenic potential of endothelial cell tubule formation in immortalized ms1 endothelial cells (brown et al. we previously investigated the effect of two structurally related compounds of the ginger family, -gingerol and -paradol, on egf-induced cell transformation and ap-1 activation (bode et al. further, -shogaol was reported to inhibit the growth of and induce apoptosis in colo 205 cells (pan et al. this idea is supported by data indicating that the reduction of uvb-induced expression and transactivation of cox-2 by -gingerol was associated with the suppression of iκbα phosphorylation (ser32) resulting in a decreased translocation of nf-κb from cytosol to nucleus in hacat cells (kim et al. this ginger derivative appeared to exert its effects by inhibition of proliferation, induction of apoptosis, and suppression of nf-κb and heme oxygenase expression in both colon and lung cancer tissues (kim et al. collectively, these findings indicate a crucial role of lta4h in cancer and also support the anticancer efficacy of -gingerol targeting of lta4h for the prevention of colorectal cancer (jeong et al. these findings were supported in a later study in which ginger was reported to have no effect on clotting status or the pharmacokinetics or pharmacodynamics of warfarin in healthy subjects (jiang, williams et al. in a comparison of gingerols and analogs with aspirin, ginger compounds were found to be less potent compared to aspirin in inhibiting arachidonic acid-induced platelet release and aggregation and cox activity (koo et al. components of ginger rhizomes are reported to contain potent compounds capable of suppressing allergic reactions and might be useful for the treatment and prevention of allergic diseases (chen et al. in a mouse model of th2-mediated pulmonary inflammation, an intraperitoneal injection of a ginger extract mainly comprised of gingerols markedly decreased the recruitment of eosinophils to the lungs in ovalbumin-sensitized mice and also suppressed the th2 cell-driven response to allergen (ahui et al. oral administration of a ginger extract (1000 mg/kg) was reported to be tolerated well by pregnant rats, and it exerted no adverse effects on the mothers or in the development of fetuses (weidner and sigwart 2001). the most common use of ginger is to alleviate the vomiting and nausea associated with pregnancy, chemotherapy, and some types of surgery. however, in spite of the lack of specific mechanistic information, use of ginger appears to be safe and its effects are mighty and amazing in its many applications.
ginger root comes from the zingiber officinale plant, and it has been used in chinese and indian medicine for thousands of years. ginger may also reduce the risk of diabetes, cancer, and other health problems. they also called for further studies in humans, in order to fully understand the effects of ginger on nausea and other gastrointestinal issues. a small 2019 study on the effects of ginger extract on smokers and nonsmokers found that daily consumption of ginger extract was associated with a stronger antibody response in nonsmokers.
meanwhile, a 2017 review of 16 clinical trials determined that the phytochemical properties in ginger may combat inflammation. a 2015 review suggests that ginger may be effective against certain cancers of the gastrointestinal system, including colorectal cancer, gastric cancer, pancreatic cancer, and liver cancer. the review concludes that ginger may inhibit the growth of cancer cells in certain types of cancer or contribute to the death of cancer cells in other types. also, studies investigating the health benefits of ginger have often been small or inconclusive. here, learn which foods to eat and avoid on… turmeric is a member of the ginger family.
ginger has been used for thousands of years for the treatment of numerous ailments, such as colds, nausea, arthritis, migraines, and hypertension. the medicinal ginger may help relieve nausea and vomiting and aid digestion . antioxidants and other nutrients in ginger root may help prevent or treat arthritis, ginger has a very long history of use in various forms of traditional and alternative medicine. it’s been used to aid digestion, reduce nausea, and help fight, ginger herbal medicine uses, ginger herbal medicine uses, when not to take ginger, side effects of ginger, how to eat ginger for health benefits.
today, health care professionals may recommend ginger to help prevent or treat nausea and vomiting from motion sickness, pregnancy, and cancer chemotherapy. it is also used to treat mild stomach upset, to reduce pain of osteoarthritis, and may even be used in heart disease. the ginger spice comes from the roots of the plant. it’s used as a food flavoring and medicine. ginger contains chemicals that might reduce nausea and swelling. committee on herbal medicinal products (hmpc). herbal medicine: summary for the public. ginger. zingiber officinale roscoe, rhizoma. herbal remedy: ginger ginger is a powerful appetite stimulant and helps with other digestive upsets such as indigestion, heartburn and low, ginger health benefits and side effects, benefits of ginger tea, ginger vitamins, benefits of eating raw ginger in empty stomach, ginger root, how much ginger should i take daily, ginger benefits for men, benefits of ginger and honey, research articles on ginger pdf, eating raw ginger benefits.
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