to answer these questions in this chapter, we will review and discuss treatment of liver cancer from chinese medicineâs perspective with scientific evidences as following three parts: (1) chinese medicine as the source of discovering new treatment for liver cancer, (2) chinese medicine as a complementary treatment of liver cancer, and (3) to discuss future research and application of chinese medicine in liver cancer treatment. in this regard, chinese medicine has been considered as a potential curative choice of method for controlling the proliferation of liver cancer, and thus improving the quality of life and prolonging overall survival of the patients. here, we retrospectively reviewed and analyzed the functional roles of chinese medicine in the treatment of liver cancer. researchers designed and synthesized a group of matrine derivatives, which improved the antitumor activities of matrine in several human cancer cell lines. further study showed the apoptotic induction, cell cycle blocking in g0/g1 phase and the inhibition of pi3k/akt signaling were involved in the antiliver cancer effect of wm622 . the investigation revealed a potential novel mechanism by which ua controlled proliferation of hcc cells, suggesting the critical effect of dnmt1 in hcc chemoprevention and treatment . furthermore, it was corroborated that this effect was involved in downregulation of bcl-2, upregulation of p53, p21 and bax, suggesting that beps-ia may be a new dietary drug for hcc obtained from herbals and shed light on getting a deeper understanding on the action mechanisms . the study investigated the antiproliferation and inducing apoptosis effects of caa in three hepatoma cell lines. reported that bufalin exhibited considerable antitumor activities in liver cancer cell lines hcclm3 and hepg2 and the underlying mechanism might be related to the repression of signaling pathway akt/gsk3β/β-catenin/e-cadherin . measured the efficacy of glps on liver cancer cells in hepatoma-bearing mice model and effectively suppressed the tumor growth.
astragalus membranaceus and salvia miltiorrhiza are medical plants that have been applied for thousands of years in the treatment of liver diseases. in a study, total flavonoids isolated from salvia chinensisbenth were shown to own the capability of inducing hcc cell apoptosis both in vitro and in vivo, which appeared to be implicated in the suppression of nf-κb activity . realgar (as4s4), one of the most useful mineral drugs in chinese medicine, has been employed in clinical therapy as a potential agent for cancer therapy. aimed to elucidate the efficacy of pzh on the proliferation and apoptosis of liver cancer cell lines and demonstrated pzh could effectively inhibit cancer cell proliferation and induce apoptosis in bel-7402 hcc cells by upregulating mir-16, which has been verified as tumor suppressor, suggesting a novel potential therapeutic for hcc patients . shuihonghuazi formula (shhzf) has been employed for early stage of liver cancer in clinical therapy for a long time; a study was designed to investigate potent effects of shhzf on hepatoma and its metabolomic profiles. a study recently demonstrated that glp treatment may augment growth inhibition and apoptotic death of hepg2 cells, which induced by radiation, and revealed the regulatory role of akt signaling pathway for glp-mediated radiosensitivity in hcc cells exposed to radiation . explored the antitumor effect of ae-sn in combination with a normal chemotherapeutic drug, namely doxorubicin or cisplatin, in hcc cell lines hep3b and hepj5. recently, scholars used combination of sfjdc with doxorubicin to treat liver cancer cells and further explored the underlying mechanisms of sfjdc as well as its constituents in vitro. jq1, one of the bromodomain and extra-terminal domain (bet) inhibitors, has been emerged as a novel agent candidate for cancer treatment in clinical research. as summarized in table 1, formulae potentially employed in practice were studied in laboratory and the regulatory mechanisms for the treatment of liver cancer have been showed clearly.
the role of curcumin as an adjuvant remedy is explored in this article. however, in the majority of cases, tumor recurrence and relapse occurs on completion of therapy.  the notch pathway is involved in cellular differentiation, fate of the cell, cellular proliferation, apoptosis, and cell adhesion. the activated intracellular form of notch-3, and the notch ligand jagged, is highly expressed in hcc.  the wnt/catenin signaling in hb is dependent on the liver and may contribute more to the genesis of the embryonal than the fetal component of hb. tyrosine phosphorylation of beta-catenin shields beta-catenin from serine/threonine phosphorylation and subsequent degradation, and leads to beta-catenin accumulation in the tumor cells. with the use of curcumin, the levels of cyclin b1 and cdc2 in the cells were significantly reduced. curcumin has been demonstrated to inhibit the proliferation of hepg2 cells (hepatoma cell line) in a dose and time dependent manner in in vitro studies. a dose dependent decrease in the expressions of c-myc and vegf was also reported.  found that curcumin treatment inhibited the cell proliferation and induce apoptosis in cancer cells. however, the hydrophobicity and low bioavailability of curcumin are the major barriers.  liver cancer is a leading cause of death in children and adults.
although preclinical results are promising but its clinical use in the treatment of hcc and hb remains to be elucidated. poor bioavailability and hydrophobicity of curcumin are the main obstacles in its path to be used clinically as an anti-tumor agent. role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane). notch signaling regulates stem cell numbers in vitro and in vivo. activation of wnt and myc signaling in hepatoblastoma. dysregulation of the hedgehog pathway in human hepatocarcinogenesis. potential therapeutic efficacy of curcumin in liver cancer. effect of mesenchymal stem cells and novel curcumin derivative on notch1 signaling in hepatoma cell line. mitochondrial and nuclear dna damage induced by curcumin in human hepatoma g2 cells. role of prooxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane). analysis of their possible relationship to changes in nf-kb activation levels and in iap gene expression. liver cancer understaging in liver transplantation in the current era of radiologic imaging and newer generation locoregional therapies tenofovir disoproxil fumarate is not associated with a lower risk of hepatocellular carcinoma compared to entecavir in patients with chronic hepatitis b
shi-quan-da-bu-tang (tj-48, juzen-taiho-to in japanese,) is a classic herbal composite formula. it consist of 10 herbs; mongolian milkvetch root, cinnamon, berberine is a natural product in many chinese medicinal herbs, especially coptidis rhizoma , which has been extensively studied and reported to show the research in the laboratory has shown that milk thistle might help to treat some liver diseases, such as hepatitis and cirrhosis. a few trials have looked at, related conditions, related conditions, related health topics.
ginger. it was reported that ginger could be a promising candidate for cancer prevention [96,97,98]. in a chemical induced liver cancer rat model, 50 mg/kg daily treatment of ginger significantly reduced serum liver cancer markers (u03b1-fetoprotein, cea), as well as liver tissue growth factors . many phytochemicals have proven anti-tumor action including catechins, quercetin in apples and onions, resveratorl in grapes, red wine, peanuts, and ellagic extensive evidence has highlighted the clinical application of chinese herbal medicine formulas in cancer therapy. for liver cancer treatment, systemic therapies like sorafenib are the first-line treatment choice. furthermore, lenvatinib, regorafenib, ramucirumab, cabozantinib and, .
When you try to get related information on holistic medicine for liver cancer, you may look for related areas. related conditions, related health topics.