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the biosynthesis of such bzd is still unknown and the hypothesis is favoured that they may be of plant origin. in some cases identification of these compounds was accomplished by specific mass spectrometry (gc-ms) and for quantification various methods have been applied resulting in different concentrations which range for d from about 0.005 to 1 ng/g and for dd from 0.01 to 0.5 ng/g. it is very unlikely that these trace amounts exert any direct pharmacological effects and at the moment only speculations upon their physiological/biological role are possible. as long as the structure of this binding activity has not been elucidated no firm conclusions can be drawn from these findings.
the .gov means it’s official. the site is secure. benzodiazepines of natural origin (nbzds) have been found in human blood and brains as well as in medicinal plants and foods. diazepam and nordiazepam equal to commercial drugs but there are also other benzodiazepine-like compounds termed “endozepines”, which act as agonists at the benzodiazepine receptors of central type (cbr).
a synthetic pathway for the production of nbzds has not yet been found, but it has been suggested that micro-organisms may synthesize molecules with benzodiazepine-like structures. it has been suggested that nbzds may play a role in the pathogenesis of hepatic encephalopathy (he). multidirectional studies evaluated nbzds levels (1) in the blood of normal subjects, of cirrhotic with or without he and in commercial benzodiazepine consumers; (2) in the blood of cirrhotic treated or not with a non-absorbable antibiotic; (3) in several constituents of our diet. the finding that nbzds may be in part synthesized by intestinal bacterial flora and in part constituent of our diet underlines the importance to feed cirrhotic patients with selected food.
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