natural tramadol

colloquially known as the ‘african peach’ or ‘pin cushion tree’, n. latifolia is a flowering, sub-saharan evergreen that grows widely across central and west africa and is used by local populations to treat a wide variety of ailments – including epilepsy, malaria, general pain and many infectious diseases. ‘our results indicate that high amounts of the analgesic drug, tramadol, can be obtained through a simple extraction procedure from nauclea latifolia found in cameroon or sub-saharan areas,’ says michel de waard, a neuroscientist at the université joseph fourier. de waard adds that the root of the plant could be viably used as a source of tramadol because of the significantly high concentrations of the drug – over 1% of the original dry content.




further spectroscopic and isotope ratio analyses confirmed that the compound extracted was indeed natural in origin, and not a by-product of cross-contamination. while it is probably too early to speculate on the widespread cultivation of n. latifolia to make tramadol, the team have developed a simplified process for extracting the drug and are hopeful this might be of benefit to local communities. ‘this report…shows that the subject of ethnopharmacology still has much to offer biomedical research in terms of drug discovery.’ while the study focussed exclusively on n. latifolia from cameroon, several other species of nauclea also grow across africa and the team are now investigating if they also make tramadol, as well as just how the plant makes the drug.

every so often reports appear that some synthetic compound actually turns out to be a natural product. fittingly, preparations from this same species show up in a number of traditional medicine mixtures in west africa, and there have also been numerous reports that extracts of the tree’s roots have an analgesic effect.this work was done through classic natural-products work: fractionate the root, test the fractions for activity in a rodent assay, home in on the active fraction and see what compounds are in it. it’s always good to read about this sort of thing working – a lot of natural products were discovered this way in earlier days, but it’s gotten harder over the years. further spectroscopic and isotope ratio analyses confirmed that the compound extracted was indeed natural in origin, and not a by-product of cross-contamination. one is that there are most certainly natural products that target the opioid receptors, starting with morphine and moving along from there.

by this point, we’ve isolated enough plant-derived compounds that most of the time a natural products chemist can say “oh yeah, that’s a terpenoid, looks related to such-and-such”, or “oh yeah, that’s an alkaloid of the this-and-that family”. if you find one, you make a big deal out of it. tramadol has certainly never been reported as a natural product, and it’s interesting that it is one, but looking at its structure, you could imagine that sure, a plant could make that, one way or another. derek lowe’s commentary on drug discovery and the pharma industry. © 2022 american association for the advancement of science.

. first marketed in 1977, tramadol is frequently used to relieve moderate to moderately-severe pain. while other synthetic drugs have later been found in nature last year i mentioned a paper that described the well-known drug tramadol as a natural product, isolated from a species of tree in cameroon. our results indicate that high amounts of the analgesic drug, tramadol, can be obtained through a simple extraction procedure from nauclea, tramadol side effects, tramadol side effects, nauclea latifolia, phenylalanine, iboga.

we have independently investigated the source of tramadol, a synthetic analgesic largely used for treating moderate to severe pain in humans, recently found they detected tramadol, a synthetic narcotic recently reclassified as a controlled substance, in the roots of an african medicinal plant (angew. the root bark of the pincushion tree, nauclealatifolia, has been shown by a team of researchers led by michel de waard, inserm research, nauclea latifolia for sale, tramadol ingredients, nauclea latifolia extract, nauclea latifolia root benefits, african peach extract, ibogaine, african pincushion tree, cameroonian plant.

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